Figure 3From: Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcersSerum levels of vascular endothelial growth factor (VEGF) according to disease duration. The analysis included patients with pre-systemic sclerosis (pre-SSc) (autoantibodies, capillaroscopy changes and Raynaud's phenomenon, but not yet fulfilling American College of Rheumatology criteria), patients with early SSc (diffuse SSc <3 years, limited SSc < 5 years) and patients with intermediate/late (imed/late) SSc (diffuse SSc ≥ 3 years, limited SSc ≥ 5 years). In all groups including patients with pre-SSc, VEGF levels were significantly increased compared with controls. No differences were found between patients with different disease duration. Data are shown as box plots, with upper and lower quartiles shaded. #P < 0.05.Back to article page