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Table 1 Ex vivo and in vivo gene transfer to the synovial lining of rabbits' knee joints*

From: Lessons learned from gene transfer approaches

 

In vivo

Ex vivo

Level of expression

High

Low-medium

Duration of expression

~ 2 weeks

Up to 6 weeks

Transduced cells

Types A+B synoviocytes

Type B synoviocytes

 

Various leukocytes

 

Laboriousness

Low

High

Inflammatory response

Present

Absent

  1. *This comparison is based upon ex vivo genetransfer using Moloney-based retrovirus, and in vivo gene transferusing first generation adenovirus.