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Table 1 Ex vivo and in vivo gene transfer to the synovial lining of rabbits' knee joints*

From: Lessons learned from gene transfer approaches

  In vivo Ex vivo
Level of expression High Low-medium
Duration of expression ~ 2 weeks Up to 6 weeks
Transduced cells Types A+B synoviocytes Type B synoviocytes
  Various leukocytes  
Laboriousness Low High
Inflammatory response Present Absent
  1. *This comparison is based upon ex vivo genetransfer using Moloney-based retrovirus, and in vivo gene transferusing first generation adenovirus.
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Arthritis Research & Therapy

ISSN: 1478-6362

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