Lessons learned from gene transfer approaches

Table 2 Intra-articular effects of various genes following direct delivery to the synovial lining of normal rabbits knees

^*Effects are graded on a scale from 0 = no effect to+++ = large stimulatory effect to - - - = large inhibitory effect.^†Delivery of the TGF-β 1 gene was associated with theintrasynovial formation of cartilage. Delivery of the iNOS gene was associatedwith neovascularization of synovium. TNF, tumor necrosis factor; TGF,transforming growth factor; IGF, insulin-like growth factor; BMP, bonemorphogenetic protein; iNOS, inducible nitric oxide synthase.