TY - JOUR AU - Krane, Stephen M. PY - 2002 DA - 2002/10/08 TI - Elucidation of the potential roles of matrix metalloproteinases in skeletal biology JO - Arthritis Res Ther SP - 2 VL - 5 IS - 1 AB - Irreversible destruction of joint structures is a major feature of osteoarthritis and rheumatoid arthritis. Fibrillar collagens in bone, cartilage and other soft tissues are critical for optimal joint form and function. Several approaches can be used to ascertain the role of collagenases, matrix metalloproteinases, in proteolysis of joint collagens in arthritis. These approaches include identifying spontaneous genetic disorders of the enzymes and substrates in humans and animals, as well as engineering mutations in the genes that encode these proteins in mice. Insights gained from such studies can be used to design new therapies to interrupt these catabolic events. SN - 1478-6354 UR - https://doi.org/10.1186/ar600 DO - 10.1186/ar600 ID - Krane2002 ER -