Figure 3From: Collagen-induced arthritis is exacerbated in IL-10-deficient miceIFN-γ levels are reduced in IL-10-/- mice. Spleens were harvested from collagen-immunized mice and restimulated with collagen ex vivo. Supernatants were harvested on day 5 and assayed by ELISA. Values are presented as the mean ± standard error of the mean of: (a) DBA/1 wildtype (WT) (n = 17), IL-10+/- (n = 12), and IL-10-/- (n = 11) mice; and (b) WT (n = 13) and IL-10-/- (n = 7) mice. * P < 0.05 in comparison with WT mice.Back to article page