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Table 1 Clinical features of patients included in the study

From: Investigation of infectious agents associated with arthritis by reverse transcription PCR of bacterial rRNA

   Reverse transcription PCR using  
   Universal primers Specific primers  
Patient Bacteria implicated DNase Non-DNase Yer Chlam E. coli Camp Clinical details
A Yersinia 6/20 2/20 +   +   Acute ReA (see [10]); positiveve serology (agglutination 1:2500) and T cell responses
B Enteric 10/20 7/20    +   Acute ReA following gastroenteritis; organism unknown
C Meningococci Negative 2/20    +   Acute postinfective arthritis; sore throat, rash, positive serology; daughter had meningococcal purpura and arthritis
D Streptococcus 17/20 5/20    +   Chronic erosive seronegative oligoarthritis; persistent positive serology – very high ASOT (>1200 U) and anti-Dnase
E Chlamydia 5/20 5/20   + +   Acute sexually acquired ReA; high T-cell mediated responses to CT
F Yersinia (?) 7/20 6/20    +   Acute (?) ReA; positive serology, B27+ and T-cell responses; no enteritis
G Unknown 12/20 1/20    +   Chronic seronegative oligoarthritis; culture positive Campylobacter infection 2 years pre-arthritis
H Unknown 11/20 5/20    +   Chronic seronegative oligoarthritis
I Yersinia 8/20 9/20    +   Acute ReA following gastroenteriitis; positive serology (IgM 1:640, IgG 1:2560, IgA <1:80) and T-cell responses
J Chlamydia 7/20 3/20    +   Acute sexually acquired ReA; high T-cell mediated responses to CT
K Campylobacter 19/20 20/20    +   Psoriatic arthritis complicated by culture positive enteritis and flare in joint symptoms (?ReA)
L Campylobacter 19/20 16/20    +   Acute ReA following enteric infection
M Campylobacter Negative Negative      Acute seronegative oligoarthritis and vasculitis; positiveve serology (IgM <1:80, IgG 1:640, IgA 1:160)
N Campylobacter Negative Negative      Sero-negative oligoarthritis; positive serology (IgM 1:640, IgG 1:640, IgA 1:160) and T-cell responses
  1. Universal (DNase and non-DNase) indicates the number of clones sequenced giving good quality sequence from PCR products obtained using universal primers R1 and R2 from each patient, with and without DNase treatment. Specific indicates results of subsequent Yersinia (Yer), Chlamydia (Chlam), Escherichia coli, and Campylobacter (Camp) specific PCR performed on the products obtained using universal primers. ASOT, antistreptolysin O titre; CT, Chlamydia trachomatis.
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Arthritis Research & Therapy

ISSN: 1478-6362

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