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Figure 5 | Arthritis Res Ther

Figure 5

From: Drugs in development: bisphosphonates and metalloproteinase inhibitors

Figure 5

Matrix metalloproteinase (MMP) inhibitor interactions. Subsites around the catalytic zinc (Zn) bind amino acids in the substrate on either side of the cleavage site. Synthetic MMP inhibitors use a zinc binding group (ZnBG) attached to modified peptides that can bind tightly to these subsites. LHS, left-hand side; P, position of residues in the peptide; RHS, right-hand side; S, subsites of the active site.

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