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Figure 5 | Arthritis Res Ther

Figure 5

From: The relationship between predicted peptide–MHC class II affinity and T-cell activation in a HLA-DRβ1*0401 transgenic mouse model

Figure 5

Structural representation of the wild-type peptides human aggrecan (hAG) 280–292 and hepatitis B surface antigen (HBsAg) 16–33, and the altered peptides HBsAg L23A and HBsAg L23A/T28R. DR4 pockets P1, P4, and P6 are the major MHC anchor positions (yellow amino acids), whereas P2, P3, P5, and P8 are solvent exposed and may contact the TCR (blue amino acids). Amino acids that differ from hAG 280–292 at TCR contact positions are indicated in red.

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