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Table 2 Responses of T-cell lines to wild-type and altered peptides

From: The relationship between predicted peptide–MHC class II affinity and T-cell activation in a HLA-DRβ1*0401 transgenic mouse model

 

hAG 280–292 TCL.1

hAG 280–292 TCL.2

HBsAg 16–33 TCL.1

Peptide antigen

Proliferation (SI)

IFN-γ (pg/ml)

Proliferation (SI)

IFN-γ (pg/ml)

Proliferation (SI)

IFN-γ (pg/ml)

hAG 280–292

27

10719

49

9827

1

0

HBsAg L23A/T28R

2

327

1

547

1

34

HBsAg L23A

1

260

1

80

1

640

HBsAg 16–33

1

0

1

61

34

7841

  1. Data shown are from a representative experiment showing the T-cell proliferative response in stimulation index (SI) and IFN-γ production after peptide challenge (10 μg/ml). hAG, human aggrecan; HBsAg, hepatitis B surface antigen.