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Table 2 Responses of T-cell lines to wild-type and altered peptides

From: The relationship between predicted peptide–MHC class II affinity and T-cell activation in a HLA-DRβ1*0401 transgenic mouse model

  hAG 280–292 TCL.1 hAG 280–292 TCL.2 HBsAg 16–33 TCL.1
Peptide antigen Proliferation (SI) IFN-γ (pg/ml) Proliferation (SI) IFN-γ (pg/ml) Proliferation (SI) IFN-γ (pg/ml)
hAG 280–292 27 10719 49 9827 1 0
HBsAg L23A/T28R 2 327 1 547 1 34
HBsAg L23A 1 260 1 80 1 640
HBsAg 16–33 1 0 1 61 34 7841
  1. Data shown are from a representative experiment showing the T-cell proliferative response in stimulation index (SI) and IFN-γ production after peptide challenge (10 μg/ml). hAG, human aggrecan; HBsAg, hepatitis B surface antigen.