Figure 2From: Urokinase, a constitutive component of the inflamed synovial fluid, induces arthritisHistopathological appearance of arthritis after intra-articular injection of low molecular weight urokinase plasminogen activator (LMW-uPA). (a) Arthritic knee joint 4 days after the LMW-uPA injection (60 pmol/joint). Infiltration of mononuclear cells in the synovial tissue is apparent. Original magnification × 10. (b) Knee joint injected with PBS revealed no signs of inflammation. Original magnification × 10. JC, joint cavity; C, cartilage; ST, synovial tissue; P, pannus. Arrows indicate inflammatory cell infiltration in the synovium and pannus formation.Back to article page