Figure 1

Treatment with protease-activated kringles 1–5 (K1–5) significantly reduces the severity of collagen-induced arthritis. From the day of arthritis onset, mice were treated intraperitoneally each day with (▲) vehicle (n = 9), (○) K1–5 at a dose of 0.2 mg/kg (n = 8) or (●) K1–5 at a dose of 2 mg/kg (n = 8), or (■) were left untreated (n = 8). The clinical score is expressed as change from day 1 (mean ± SEM). Data were analyzed by two-way analysis of variance: P < 0.001 for mice treated with 2 mg/kg K1–5, versus untreated mice, and mice treated with vehicle or 0.2 mg/kg K1–5; P > 0.10 for untreated and vehicle-treated mice, versus mice treated with 0.2 mg/kg K1–5.