Figure 3

Protease-activated kringles 1–5 (K1–5) does not significantly affect serum anticollagen IgG. From the day of arthritis onset, mice were treated with (▲) vehicle (phosphate-buffered saline [PBS]; n = 15), (○) K1–5 at a dose of 0.2 mg/kg (n = 8) or (●) K1–5 at a dose of 2 mg/kg (n = 13), or (■) were left untreated (n = 14). Serum anticollagen IgG was measured on day 10 of arthritis and is expressed as arbitrary units/ml, with reference to pooled serum from mice killed on day 10 of arthritis. Data were analyzed by one-way analysis of variance with Newman–Keul post-test for multiple comparisons: P > 0.10 for all comparisons.