Figure 5

Histological appearance of joints after administration of protease-activated kringles 1–5 (K1–5). Haematoxylin and eosin stained sections of distal phalanx, proximal phalanx, first metatarsal and tarsus joints from (a) untreated mice, (b) vehicle (phosphate buffered saline [PBS])-treated mice, and animals receiving K1–5 at a daily intraperitoneal dose of either (c) 0.2 mg/kg or (d) 2 mg/kg. All sections were obtained on day 10 of arthritis. Magnification × 40. s, synovium; e, bone erosions.