Day of arthritis | Untreated | Vehicle | K1–5 0.2 mg/kg | K1–5 2 mg/kg |
---|---|---|---|---|
Clinical score | ||||
1 | 2.38 ± 0.26** | 2.22 ± 0.28** | 2.50 ± 0.19** | 2.57 ± 0.20 |
2 | 4.08 ± 0.54** | 3.36 ± 0.43** | 3.64 ± 0.40** | 2.33 ± 0.17 |
3 | 4.71 ± 0.47** | 3.93 ± 0.48** | 4.29 ± 0.52** | 2.14 ± 0.18 |
4 | 4.93 ± 0.69** | 4.11 ± 0.52** | 4.93 ± 0.44** | 2.75 ± 0.75 |
5 | 5.29 ± 0.62** | 4.44 ± 0.54** | 5.19 ± 0.58** | 3.25 ± 0.51 |
6 | 5.00 ± 0.45** | 4.89 ± 0.54** | 5.70 ± 0.44** | 3.75 ± 0.51 |
7 | 5.57 ± 0.47** | 5.33 ± 0.82** | 5.67 ± 1.17** | 4.33 ± 0.38 |
8 | 5.63 ± 0.45** | 5.00 ± 0.65** | 5.56 ± 0.95** | 3.33 ± 0.38 |
9 | 5.31 ± 0.59** | 6.50 ± 0.79** | 5.75 ± 0.85** | 4.00 ± 0.64 |
10 | 5.60 ± 0.68** | 5.81 ± 0.98** | 6.50 ± 1.03** | 3.90 ± 0.91 |
Paw thickness (mm) | ||||
1 | 1.93 ± 0.04** | 1.88 ± 0.06* | 1.94 ± 0.06** | 1.91 ± 0.04 |
2 | 2.20 ± 0.11** | 2.05 ± 0.08* | 2.11 ± 0.11** | 1.96 ± 0.08 |
3 | 2.25 ± 0.11** | 2.11 ± 0.11* | 2.19 ± 0.10** | 1.91 ± 0.09 |
4 | 2.36 ± 0.13** | 2.19 ± 0.10* | 2.30 ± 0.13** | 1.92 ± 0.10 |
5 | 2.34 ± 0.14** | 2.22 ± 0.12* | 2.33 ± 0.10** | 2.14 ± 0.13 |
6 | 2.22 ± 0.14** | 2.25 ± 0.12* | 2.47 ± 0.12** | 2.16 ± 0.12 |
7 | 2.49 ± 0.11** | 2.23 ± 0.14* | 2.50 ± 0.12** | 2.21 ± 0.12 |
8 | 2.43 ± 0.12** | 2.33 ± 0.12* | 2.41 ± 0.11** | 2.20 ± 0.12 |
9 | 2.37 ± 0.12** | 2.40 ± 0.09* | 2.41 ± 0.10** | 2.20 ± 0.11 |
10 | 2.45 ± 0.15** | 2.40 ± 0.09* | 2.42 ± 0.11** | 2.19 ± 0.16 |