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Table 1 Effect of protease-activated kringles 1–5 treatment on clinical score and paw thickness

From: The angiogenesis inhibitor protease-activated kringles 1–5 reduces the severity of murine collagen-induced arthritis

Day of arthritis

Untreated

Vehicle

K1–5 0.2 mg/kg

K1–5 2 mg/kg

Clinical score

    

   1

2.38 ± 0.26**

2.22 ± 0.28**

2.50 ± 0.19**

2.57 ± 0.20

   2

4.08 ± 0.54**

3.36 ± 0.43**

3.64 ± 0.40**

2.33 ± 0.17

   3

4.71 ± 0.47**

3.93 ± 0.48**

4.29 ± 0.52**

2.14 ± 0.18

   4

4.93 ± 0.69**

4.11 ± 0.52**

4.93 ± 0.44**

2.75 ± 0.75

   5

5.29 ± 0.62**

4.44 ± 0.54**

5.19 ± 0.58**

3.25 ± 0.51

   6

5.00 ± 0.45**

4.89 ± 0.54**

5.70 ± 0.44**

3.75 ± 0.51

   7

5.57 ± 0.47**

5.33 ± 0.82**

5.67 ± 1.17**

4.33 ± 0.38

   8

5.63 ± 0.45**

5.00 ± 0.65**

5.56 ± 0.95**

3.33 ± 0.38

   9

5.31 ± 0.59**

6.50 ± 0.79**

5.75 ± 0.85**

4.00 ± 0.64

   10

5.60 ± 0.68**

5.81 ± 0.98**

6.50 ± 1.03**

3.90 ± 0.91

Paw thickness (mm)

    

   1

1.93 ± 0.04**

1.88 ± 0.06*

1.94 ± 0.06**

1.91 ± 0.04

   2

2.20 ± 0.11**

2.05 ± 0.08*

2.11 ± 0.11**

1.96 ± 0.08

   3

2.25 ± 0.11**

2.11 ± 0.11*

2.19 ± 0.10**

1.91 ± 0.09

   4

2.36 ± 0.13**

2.19 ± 0.10*

2.30 ± 0.13**

1.92 ± 0.10

   5

2.34 ± 0.14**

2.22 ± 0.12*

2.33 ± 0.10**

2.14 ± 0.13

   6

2.22 ± 0.14**

2.25 ± 0.12*

2.47 ± 0.12**

2.16 ± 0.12

   7

2.49 ± 0.11**

2.23 ± 0.14*

2.50 ± 0.12**

2.21 ± 0.12

   8

2.43 ± 0.12**

2.33 ± 0.12*

2.41 ± 0.11**

2.20 ± 0.12

   9

2.37 ± 0.12**

2.40 ± 0.09*

2.41 ± 0.10**

2.20 ± 0.11

   10

2.45 ± 0.15**

2.40 ± 0.09*

2.42 ± 0.11**

2.19 ± 0.16

  1. From the day of arthritis onset, mice were treated intraperitoneally each day with either vehicle (phosphate buffered saline [PBS]), protease-activated kringles 1–5 (K1–5) at a dose of either 0.2 mg/kg or 2 mg/kg, or were left untreated. The absolute values for clinical scores and paw thickness are shown. Data were analyzed by two-way analysis of variance: *P < 0.01, **P < 0.001, versus mice treated with 2 mg/kg K1–5; all other values P > 0.10. For numbers of mice in each group, see the legends to Figs 1 and 2.