Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology

Table 5 Summary of immunohistochemistry results demonstrating how the distribution of different epitopes varies with morphology, ranging from normal articular cartilage through to fibrocartilage

Collagen or glycosaminoglycan epitope	'Normal' articular cartilage	Hyaline-like repair tissue	Hyaline/fibrocartilage repair tissue	Fibrocartilage-like repair tissue	Meniscus (fibro-cartilage)
Collagen
I	-	-	-/+	+	++
II	++	++	+	+	+/-
III	+pc	+pc	+pc/+	+	++
VI	+pc	+pc	+pc/+	+	+pc
X	+pc	+pc	+pc/-	-	-
Glycosaminoglycan
Chondroitin-4-sulfate: (2-B-6)	++	++	+	+	++
Chondroitin-6-sulfate: (3-B-3)	+	++pc	+pc/(+)	++	+
Chondroitin-6-sulfate: (3-B-3(-))	(+)/-	(+)/-	+/-	(+)/-	-
Chondroitin-6-sulfate: (7-D-4)	+	(+)	-/(+)	-	-
Keratan sulfate: (5D4)	++	+(+)	+/(+)	+	(+)

- None or negligible (5% of section area); (+) slight; + some; ++strong; pc pericellular.

ISSN: 1478-6362