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Figure 2 | Arthritis Res Ther

Figure 2

From: Differential recovery of glycosaminoglycan after IL-1-induced degradation of bovine articular cartilage depends on degree of degradation

Figure 2

Mean glycosaminoglycan concentration ([GAG]) in IL-1-exposed samples measured at weekly intervals using delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC). The mean [GAG] increase with recovery time for samples subjected to (A) mild (3 and 6 days of 10 ng/ml IL-1, n = 4; P = 0.06) or (B) moderate (6 and 9 days of 20 ng/ml IL-1, n = 10; P = 0.0001) degradation, and then permitted to recover for 3 weeks in culture. The mean [GAG] for a given sample at a given time point was computed as the mean of [GAG] measured across all pixels of the image; error bars are ± SD between sample means. Shaded regions represent initial [GAG]; 92 ± 11 mg/ml for 'mild' series and 57 ± 6 mg/ml for 'moderate' series.

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