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Table 5 AGE-IgG is associated with the inflammatory response, whereas anti-AGE-IgG is associated with rheumatoid factor positive rheumatoid arthritis

From: Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis

 

Serum finding

Characteristic

IgG-AGE+ (n = 47)

IgG-AGE- (n = 191)

Anti-IgG-AGE+ (n = 65)

anti-IgG-AGE- (n = 173)

Females (%)

55

68

71

64

Age (years)

39 ± 12

43 ± 14

41 ± 13

43 ± 14

Swollen joint count

8.2 ± 8.7

7.2 ± 8.9

11.0 ± 11*

6.2 ± 7.6

ESR (mm/hour)

51 ± 38*

36 ± 27

45 ± 30

37 ± 30

CRP (md/dl)

2.5 ± 3.1*

1.5 ± 1.8

1.7 ± 2.0

1.8 ± 2.3

Hemoglobin (mg/dl)

13.0 ± 1.9

12.5 ± 1.5

12.7 ± 1.5

12.9 ± 1.6

Glucose (mg/dl)

100 ± 30

102 ± 40

99 ± 25

102 ± 42

IgG (mg/dl)

1427 ± 529*

1182 ± 378

1252 ± 369

1226 ± 443

IgM (mg/dl)

139 ± 61

152 ± 88

173 ± 61*

140 ± 88

IgA (mg/dl)

285 ± 139

236 ± 104

282 ± 126

232 ± 106

RF+ (%)

19 (40%)

69 (36%)

45 (69%)*

25%

anti-AGE-IgG1+ (n)

18 (26%)

40 (21%)

50 (77%)

-

anti-AGE-IgG3+ (n)

12 (26%)

38 (20%)

49 (76%)

-

  1. Values are expressed as means ± SD, unless otherwise stated. *P < 0.05, by analysis of variance or χ2 test, with Yates correction where appropriate; comparisons are between AGE-IgG+ and AGE-IgG- patients, and between anti-AGE-IgG+ and anti-AGE-IgG- patients. AGE, advanced glycation end-product; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; RF, rheumatoid factor.
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Arthritis Research & Therapy

ISSN: 1478-6362

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