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Table 1 Variable region heavy chain genes identified from spleen tissue

From: The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus

GC/cluster VH gene DH gene JH gene Number of sequences isolated
A VH2–5*02 3–10*01 5*02 1
  VH3–15*01 2–21*02 4*02 3
  VH3–23*01 1–26*01 5*02 3
  VH3–30*03 3–22*01 4*02 1
  VH3–43*02    1
  VH3–74*02 2–15*01 6*02 2
  VH5–51 3–10 4*02 4
B VH2–5*02 1–26*01 5*01 3
  VH3–21*01    2
  VH3–30*03 2–8*01 6*02 1
  VH3–30*03 2–8*01 4*02 1
  VH3–30.3*01 3–3*01 6*02 8
  VH4–30.1 2–2*01 4*02 1
C VH2–5*02   5*02 2(1)
  VH3–15*01    1
  VH3–21*01    1
  VH3–23*01   2*01 1
  VH3–23*01 3–10*02 6*03 9
  VH3–30*03   3*02 1
  VH3–30*03    2
  VH3–33*01 5–24*01 3*02 1
  VH3–74*01    (1)
  VH4–4*03   4*02 1
  VH4–30.4*01 2–2*01 6*02 5(3)
  VH4–34*01   5*02 1
  VH4–59 1–26*01 4*02 1
  VH5–51*01 2–2*01 4*02 11
  VH5–51*01 2–2*01 4*02 3(1)
  VH5–51*01 4–4*01 3*02 2
D VH3–07 2–15 3*02 13(10)
  VH3–23 3–22 6*03 3(1)
  VH3–33 6–13*01 4*02 2
  VH3–72*01 5–5*01 4*02 1
  VH4–59*02 5–24*01 4*02 1
  VH5–51*01 2–2*01 1*01 3(2)
  VH5–51*01 6–13*01 4*02 1
  1. The best matching germline sequences identified from blast searching the Vbase database from which the rearranged V-D-J sequences identified from germinal centre (GC) A and GC B, and B-cell clusters C and D were derived. Groups of sequences were deemed to be clonally related when they used the same V, D, J and CDR3, and differed only by base substitutions. The total number of members of each clone is given in the right-most column, and the number of these members that are nonfunctional is indicated in brackets. Identical sequences are only counted once.