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Table 2 The replacement : silent ratios of sequences from each of the systemic lupus erythematosus splenic germinal centres and B-cell clusters

From: The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus

  Location
GC/cluster Total VH Segment Framework CDR1and CDR2
A    
R/S ratio of all sequences 3.11 7.6 2.9
Clone VH5–51 2.5 5 1.4
Clone VH3–15 2 2 1
Clone VH3–23 2 1:0 1:0
R/S of all clones 2.75 5 1.4
B    
R/S ratio of all sequences 3.6 2.6 8.1
Clone VH2–5 4.7 4:0 4.5
Clone VH3–3.30 2.8 1.5 12
R/S of all clones 3 1.7 9
C    
R/S ratio of all sequences 2.9 3 3.2
VH5–51–JH4 4.5 8 1
VH3–23 2.7 2.4 4
VH5–51–D2–2 23.5 22 3:0
VH4–30 3 2 6
R/S of all clones 6 6.4 4.6
D    
R/S ratio of all sequences 2. 9 2.9 2.9
VH3–07 2.4 1.7 7
VH3–23 4.5 3.5 2:0
VH5–51 2.75 2 3:0
R/S of all clones 2.8 2.1 12
  1. Replacement : silent ratios (R/S ratios) were calculated for the complete VH segment as well as individual complementarity determining regions (CDRs) and framework regions. The ratios for each individual clone are shown as well as the R/S value of all the clones together, disregarding individual sequences. The colons represent instances where there are no silent replacements, therefore no figure can be given since it is not possible to divide by zero.