Domain arrangements of ADAMTS, ADAMs and MMPs. N-linked glycosylation sites (◇) and post-translational processing sites of ADAMTS-1 and ADAMTS-4 (↑) are indicated. Some ADAMTSs have PLAC and CUB domain at the C terminus. ADAMs are type I membrane proteins but ADAMTSs lack a transmembrane domain. MMP-2 and MMP-9 have three repeats of a fibronectin type II-like domain and membrane-type MMPs have a transmembrane domain and a cytoplasmic tail. SP, signal peptide; Dis, disintegrin-like domain; TS, thrombospondin type I motif; Cys, cysteine-rich domain; PLAC, proteinase and lacunin domain; CUB, complement C1r/C1s-urchin epidermal growth factor-bone morphogenetic protein-1 domain; TM, transmembrane domain; Fn, fibronectin.