Aggrecanases and cartilage matrix degradation

Table 1 Biological activities of ADAMTSs

Enzyme	Substrate	Activity	Reference
ADAMTS-1	Aggrecan, versican, α₂-macroglobulin	Cleavage of proteoglycan core proteins, anti-angiogenic	[25, 45, 50, 51]
ADAMTS-2	Procollagen I, procollagen II	Processing of N-propeptide of procollagen	[39]
ADAMTS-3	Procollagen II	Processing of N-propeptide of procollagen	[40]
ADAMTS-4	Aggrecan, versican, brevican	Cleavage of proteoglycan core proteins	[20, 52, 50]
ADAMTS-5	Aggrecan	Cleavage of aggrecan core protein	[21]
ADAMTS-8		Anti-angiogenic	[45]
ADAMTS-13	von Willebrand factor	Reduced activity results in thrombotic Thrombocytopaenic purpura	[43]
ADAMTS-14	Procollagen I	Procollagen N-proteinase	[41]

ISSN: 1478-6362