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Table 1 Biological activities of ADAMTSs

From: Aggrecanases and cartilage matrix degradation

Enzyme Substrate Activity Reference
ADAMTS-1 Aggrecan, versican, α2-macroglobulin Cleavage of proteoglycan core proteins, anti-angiogenic [25, 45, 50, 51]
ADAMTS-2 Procollagen I, procollagen II Processing of N-propeptide of procollagen [39]
ADAMTS-3 Procollagen II Processing of N-propeptide of procollagen [40]
ADAMTS-4 Aggrecan, versican, brevican Cleavage of proteoglycan core proteins [20, 52, 50]
ADAMTS-5 Aggrecan Cleavage of aggrecan core protein [21]
ADAMTS-8   Anti-angiogenic [45]
ADAMTS-13 von Willebrand factor Reduced activity results in thrombotic Thrombocytopaenic purpura [43]
ADAMTS-14 Procollagen I Procollagen N-proteinase [41]
  1. ADAMTS, a disintegrin and metalloproteinase domain with thrombospondin motif.