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Table 2 Summary of epidemiological studies of scleroderma and solvent exposure

From: Epidemiology of organic solvents and connective tissue disease

  Men Women  
Agent/Study OR 95% Cl OR 95% Cl    Comments on exposure assessment
Any solvent      
   Lundberg et al [43] NR   NR      JEM
   Nietert et al [38] 2.9 1.2-7.1 0.6 0.2-1.9    JEM. Maximum intensity of exposure
   Silman and Jones [39] 1.7 0.7-4.1 * *    ER. (General practitioner controls)
   Silman and Jones [39] 2.3 0.9-6.2 * *    ER. (Friend controls)
   Garabrant et al (manuscript submitted) * * 2.0 1.5-2.5    ER
Paint thinners and removers      
   Garabrant et al (manuscript submitted) * * 2.0 1.5-2.6    ER
Aliphatic hydrocarbons      
   Lundberg et al [43] 2.1 0.8-5.5 NR      JEM. It is not clear that the authors could
         differentiate aliphatic hydrocarbons from
         other solvents
Gasoline      
   Lundberg et al [43] NR   NR      JEM
   Garabrant et al (manuscript submitted) * * 1.3 0.7-2.6    ER
Benzene      
   Nietert et al [38] 2.4 0.8-7.1 1.1 0.3-3.9    JEM. Maximum intensity of exposure
   Garabrant et al (manuscript submitted) * * 0.8 0.2-2.6    ER
Trichloroethylene      
   Nietert et al [38] 3.3 1.0-10.3 0.9 0.3-2.3    JEM. Maximum intensity of exposure
   Garabrant et al (manuscript submitted) * * 1.9 0.6-6.6    ER
Trichloroethane      
   Nietert et al [38] 2.7 1.4 0.4-4.6    JEM. Maximum intensity of exposure
   Garabrant et al (manuscript submitted) * * 0.9 0.3-2.8    ER
  1. NR, not reported (presumed non-significant); ER, expert review ofself-reported exposure; JEM, Exposures assigned by use of job exposure matrixwithout self reported exposure; OR, odds ratio. *Not studied;confidence interval (CI) not given.