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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation

Figure 2

Model for cytokine signal transduction. Cytokines associate withcytokine receptor subunits and activate janus kinases (Jaks). The Jaks in turnphosphorylate tyrosine-based docking sites on the receptor. signal transducersand activators of transcription (Stats) then bind via their src homology (SH)2 domains. The STATs are then phosphorylated by the JAKs, formhomo-hetero-dimers and then translocate into the nucleus, where they bindtarget sequences like γ activated sequence (GAS) motif. Transcriptionalactivation of genes typically requires the coordinated function of multipleaccessory transcription factors. Additionally, serine phosphorylation of someStats may be important for maximal transcription of target genes.

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