Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Figure 2 | Arthritis Research & Therapy

Figure 2

From: Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation

Figure 2

Model for cytokine signal transduction. Cytokines associate withcytokine receptor subunits and activate janus kinases (Jaks). The Jaks in turnphosphorylate tyrosine-based docking sites on the receptor. signal transducersand activators of transcription (Stats) then bind via their src homology (SH)2 domains. The STATs are then phosphorylated by the JAKs, formhomo-hetero-dimers and then translocate into the nucleus, where they bindtarget sequences like γ activated sequence (GAS) motif. Transcriptionalactivation of genes typically requires the coordinated function of multipleaccessory transcription factors. Additionally, serine phosphorylation of someStats may be important for maximal transcription of target genes.

Back to article page