Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Figure 3 | Arthritis Research & Therapy

Figure 3

From: Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation

Figure 3

Signal transducer and activator of transcription (Stat) binding toDNA. In this two-dimensional model, the heterodimerized or homodimerized Statmolecule binds to the appropriate DNA sequence via a 'C clamp'structure. Note that in addition to the specificity controlled by the DNAbinding domain, other regions of the Stat molecule may also be important in DNAinteractions. Tetramerization of the Stats may allow for an even greater degreeof stability in DNA binding to adjacent imperfect Stat binding sites; this ismediated by the Stat amino-terminus (not shown). Also not shown in thisillustration is the Stat transcriptional activation domain.

Back to article page