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Table 1 Association of Janus kinases (Jaks), Signal transducers and activators of transcription (Stats), and suppressors of cytokine signaling (SOCSs) with cytokine receptors and phenotype of knockout mice.

From: Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation

Jak/Stat/SOCS Cytokines Deficient mice
Jak1 γccytokines, gp130 cytokines, IL-10, IFN- α , IFN- β , IFN- γ, IL-13 Neurologic defect (?), mice die perinatally
Jak2 Erythropoietin, βccytokines, gp130 cytokines, IL-13, IL-12, GH, prolactin, thrombopoietin, IFN- γ Embryonically lethal, failed to develop red blood cells
Jak3 IL-2, IL-7, IL-15, γc cytokines SCID
Tyk2 gp130 cytokines, IL-13, IL-12, IFN-α, IFN-β, IL-10 Not yet reported
Stat1 IFN- α , IFN- β , IFN- γ , IL-2, IL-6, IL-10 Susceptibility to viral and some bacterial infections
   Defective signaling in response to IFNs
   Impaired tumor rejection
Stat2 IFN-α, IFN-β Defective signaling in response to IFNs*
Stat3 LIF, IL-10, IL-6, other gp130 cytokines, γc cytokines, GH Embryonically lethal
   Targeted disruption in macrophages and neutrophils showed defective
   IL-6 and IL-10 signaling
   Chronic enterocolitis
   Conditional knockouts showed suppressed epithelial apoptosis and
   delayed mammary gland involution
Stat4 IL-12 Defective Th1 development
Stat5a Prolactin, other γc cytokines, otherβc cytokines, GH, thrombopoietin Defective lobuloalveolar development in breast
Stat5b GH, other γc cytokines,βc cytokines, prolactin, thrombopoietin Required for sexual dimorphism
Stat5a/b GH, IL-2, erythropoietin Infertile, smaller body size
   Impaired cell-cycle progression of peripheral T cells
   Fetal anemia (?)
Stat6 IL-4, IL-13 Defective Th2 development
Stat4/6   No Th2 cells in vitro
SOCS-1 IFN- γ, IL-6, GH, thrombopoietin, OSM, LIF Perinatal lethality, hyper-responsiveness to IFN-γ
SOCS-3 Erythropoietin, GH, IL-2, leptin, CNTF, IL-11, IL-10 Embryonic lethality, ? due to erythrocytosis
  1. γ Chain (γc) cytokines: interleukin (IL)- 2,IL- 4, IL- 7, IL- 9, IL- 15. gp130 cytokines: IL- 6, IL- 11, oncostatin M(OSM), ciliary neurotropic factor (CNTF), leukemia inhibitory factor (LIF), CT-1, IL- 12, Leptin. β chain (βc) cytokines: IL- 3, IL- 5,granulocyte- macrophage colony- stimulating factor (GM- CSF). Bold lettersindicate cytokines that have been shown to be essential in knockouts.*Schindler C, personal communication. SCID, severe combinedimmunodeficiency; FGF, fibroblast gowth factor; GH, growth factor; IFN,interferon.