Figure 2
Analyses of paired samples of blood (B) and synovial fluid (SF) Bcells from the same rheumatoid arthritis patient. Results using both thegenomic DNA-based assay and the complementary (c)DNA-based assay for the threemajor immunoglobulin isotypes (M, G, and A) are shown. Note that certainclones, as represented by individual HCDR3 lengths, are restricted to the blood(â–¶), others to the joint (â–·), and others are common to both compartments(â—†). E, expanded clone; A, activated clone; E+A, same clone that is bothexpanded and activated.