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Table 1 Effect of hyaluronic acid (HYA) and chondroitin-4-sulphate (C4S) administration on plasma levels of galactosamine and glucosamine in rats subjected to collagen-induced arthritis (CIA), at the end of the experiment (day 21)

From: Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats

  Concentration in plasma (mg/l) Increase (%)
Experimental group Galactosamine Glucosamine Galactosamine Glucosamine
Control 9.81 ± 1.11 10.35 ± 1.71   
CIA + vehicle 12.58 ± 1.45* 14.79 ± 2.01*   
CIA + HYA 14.68 ± 2.74 19.34 ± 3.27 +17 +31
CIA + C4S 16.34 ± 3.18 14.97 ± 3.16 +30 +1
CIA + HYA + C4S 15.39 ± 1.86 19.24 ± 3.36 +22 +30
  1. Where added, the concentrations of HYA and C4S were each 25 mg/kg. Values are means ± SD for seven rats for each group. Significance: *P < 0.01 versus control; P < 0.05 versus CIA + vehicle.