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Table 2 Deregulated genes in the arthritic SF as revealed by differential display RT-PCR

From: Functional analysis of an arthritogenic synovial fibroblast

Clone no. RN N Deregulationa RT-PCR Gene ID Accession no.
6 + + > 1   NADH dehydrogenase S2 M22756
7 + + 1.3 (+) FIN 13 U42383
8 + + > 1   Aldose Reductase U93231.1
9,17,19 + + 2.1/4.8/8.6   Ribosomal protein L3 U89417
10 + + 2.7   NADH dehydrogenase S4 AF100726
13   + 4   SPARC/osteonectin X04017
14,39,71 + + -5   MHC-1b H2-T23 (Qa1-like) U12822
15,35 + + 2.2   EST~GMP reductase AA240130
16 + + - 70   mt. cytochrome b AF159396.1
18 + + > 1   ATP-specific succinyl-CoA synthetase β AF058955
20,25 + + 1.6/5   Hsp70 M34561
21,58 + + 1.8/6.3   HnRNP D-like / JKTBP AB017020
22,24 + + 2.26 + ZO-2 U75916
23 + + 10 + HSPC194 AF151028
27 + + 4   Unknown  
28 + + -14.7   Smoothelin large isoform L2 AF064236.1
29 + ? < -1 + EST~RNA binding protein L17076/S72641
29b + ? < -1   EST AI013881
31 (+) + > 1 + Unknown  
32,33 + + 3 + Unknown  
34 + (+) > 1   Unknown  
36 + ? > 1   Unknown  
37 + ? > 1   Hypothalamus protein HT001 AF113539
38 + ? < -1   Ran-GTP binding protein Y08890
      Karyopherin b3 NM002271.1
41 + (+) > 1   Huntingtin int. prot. 1 family AF049613
      HSPC136 AF161485
42 + + > 1   Unknown  
43 (+) + < -1   Pyruvate kinase (PK3)-M2 subunit NM011099
44 +   > 1   HSPC030 AF170920
45,46,47 + + 2.1   Ribosomal protein L7a X15013.1
48 + + 36 (+) Homologue to eIF6/integrin b4 int. prot. AF081140
49 + + 8.8 + HSPC249 (from CD34+ stem cells) AF151083
50 +   > 1   Unknown  
51 + ? > 1   Unknown  
52 + + 72? (+) EAP330 of ELL NM007241
53 + + > 1   Ferritin heavy chain NM010239
54 (+) + - 7.9   Ly-6E.1 alloantigen X04653
      TAP (T cells activating pr) M59713.1
55 (+) ? < -1   E124 (etoposide induced/+p53) U41751
56 + ? > 1   EST AA960119
57 (+) ? > 1   mt DNA polymerase γ U53584
60 + ? > 1   EST AA963457
61 (+) + 2.3   Karyopherin a4 (importin a3)? NM002268
62 + + 3.5 + LIM-protein? AF037208
65 + + 22   MEKK4? NM011948
66 + ? > 1   Human mRNA expr. in thyroid gland D83198
66b + ? > 1   Human cDNA FLJ20657 fis AK000664
67 + ? > 1   Unknown  
68 + ? > 1   Unknown  
69 + (+) > 1   Unknown  
70 + ? < -1   MHC class II AF110520
  1. aFold of up/down-regulation, as calculated from Northern blots after normalization against glyceraldehyde-3-phosphate dehydrogenase. N, Northern; RN, reverse Northern; RT-PCR, reverse transcriptase polymerase chain reaction.