Table 2 Deregulated genes in the arthritic SF as revealed by differential display RT-PCR
From: Functional analysis of an arthritogenic synovial fibroblast
Clone no. | RN | N | Deregulationa | RT-PCR | Gene ID | Accession no. |
|---|---|---|---|---|---|---|
6 | + | + | > 1 | Â | NADH dehydrogenase S2 | M22756 |
7 | + | + | 1.3 | (+) | FIN 13 | U42383 |
8 | + | + | > 1 | Â | Aldose Reductase | U93231.1 |
9,17,19 | + | + | 2.1/4.8/8.6 | Â | Ribosomal protein L3 | U89417 |
10 | + | + | 2.7 | Â | NADH dehydrogenase S4 | AF100726 |
13 | Â | + | 4 | Â | SPARC/osteonectin | X04017 |
14,39,71 | + | + | -5 | Â | MHC-1b H2-T23 (Qa1-like) | U12822 |
15,35 | + | + | 2.2 | Â | EST~GMP reductase | AA240130 |
16 | + | + | - 70 | Â | mt. cytochrome b | AF159396.1 |
18 | + | + | > 1 |  | ATP-specific succinyl-CoA synthetase β | AF058955 |
20,25 | + | + | 1.6/5 | Â | Hsp70 | M34561 |
21,58 | + | + | 1.8/6.3 | Â | HnRNP D-like / JKTBP | AB017020 |
22,24 | + | + | 2.26 | + | ZO-2 | U75916 |
23 | + | + | 10 | + | HSPC194 | AF151028 |
27 | + | + | 4 | Â | Unknown | Â |
28 | + | + | -14.7 | Â | Smoothelin large isoform L2 | AF064236.1 |
29 | + | ? | < -1 | + | EST~RNA binding protein | L17076/S72641 |
29b | + | ? | < -1 | Â | EST | AI013881 |
31 | (+) | + | > 1 | + | Unknown | Â |
32,33 | + | + | 3 | + | Unknown | Â |
34 | + | (+) | > 1 | Â | Unknown | Â |
36 | + | ? | > 1 | Â | Unknown | Â |
37 | + | ? | > 1 | Â | Hypothalamus protein HT001 | AF113539 |
38 | + | ? | < -1 | Â | Ran-GTP binding protein | Y08890 |
| Â | Â | Â | Â | Â | Karyopherin b3 | NM002271.1 |
41 | + | (+) | > 1 | Â | Huntingtin int. prot. 1 family | AF049613 |
| Â | Â | Â | Â | Â | HSPC136 | AF161485 |
42 | + | + | > 1 | Â | Unknown | Â |
43 | (+) | + | < -1 | Â | Pyruvate kinase (PK3)-M2 subunit | NM011099 |
44 | + | Â | > 1 | Â | HSPC030 | AF170920 |
45,46,47 | + | + | 2.1 | Â | Ribosomal protein L7a | X15013.1 |
48 | + | + | 36 | (+) | Homologue to eIF6/integrin b4 int. prot. | AF081140 |
49 | + | + | 8.8 | + | HSPC249 (from CD34+ stem cells) | AF151083 |
50 | + | Â | > 1 | Â | Unknown | Â |
51 | + | ? | > 1 | Â | Unknown | Â |
52 | + | + | 72? | (+) | EAP330 of ELL | NM007241 |
53 | + | + | > 1 | Â | Ferritin heavy chain | NM010239 |
54 | (+) | + | - 7.9 | Â | Ly-6E.1 alloantigen | X04653 |
| Â | Â | Â | Â | Â | TAP (T cells activating pr) | M59713.1 |
55 | (+) | ? | < -1 | Â | E124 (etoposide induced/+p53) | U41751 |
56 | + | ? | > 1 | Â | EST | AA960119 |
57 | (+) | ? | > 1 |  | mt DNA polymerase γ | U53584 |
60 | + | ? | > 1 | Â | EST | AA963457 |
61 | (+) | + | 2.3 | Â | Karyopherin a4 (importin a3)? | NM002268 |
62 | + | + | 3.5 | + | LIM-protein? | AF037208 |
65 | + | + | 22 | Â | MEKK4? | NM011948 |
66 | + | ? | > 1 | Â | Human mRNA expr. in thyroid gland | D83198 |
66b | + | ? | > 1 | Â | Human cDNA FLJ20657 fis | AK000664 |
67 | + | ? | > 1 | Â | Unknown | Â |
68 | + | ? | > 1 | Â | Unknown | Â |
69 | + | (+) | > 1 | Â | Unknown | Â |
70 | + | ? | < -1 | Â | MHC class II | AF110520 |