Table 4 Functional clustering of deregulated genes in the arthritic synovial fibroblasts
From: Functional analysis of an arthritogenic synovial fibroblast
Stress response | Protein synthesis |
|---|---|
DD(M34561) Hsp70 | DDU89417) Ribosomal protein L3 (x3) |
DD(AF170920) HSPC030 | DD(X15013.1) Ribosomal protein L7a (x3) |
DD(AA240130) EST~GMP reductase Reductase | MA(U93862) Ribosomal protein L41 |
DD(U93231.1) Aldose | MA(AA048927) Aminoacyl-tRNA synthetase |
DD(NM010239) Ferritin heavy chain | DD(AF081140) Homologue to eIF6/integrin b4 int. prot. |
Energy production | MA(U63323) Translation initiation factor (Eif4g2) |
DD,.MA(U53584) Mt DNA polymerase γ | MA (AA408104) Translational initiation factor (eIF-2) α |
DD(M22756) NADH dehydrogenase S2 | MA (AA254996) Alanyl-tRNA synthetase |
DD(AF100726) NADH dehydrogenase S4 | Protein degardation |
DD(AF058955) Succinyl-CoA synthetase β | MA (U19854) ubiquitinating enzyme E2-20K |
DD (AF159396.1) Mt. Cytochrome b | MA (X97042) UBcM4 |
MA (X01756) Cytochrome c (MC1) | MA (AA198790)ubiquinol-cytochrome c reductase (6.4) |
MA (U03283) C3H cytochrome P450 (Cyp1b1) | MA (AA237529)ubiquinol-cytochrome c reductase (7.2) |
Transcription | Growth control |
DD(NM007241) EAP330 of ELL | DD, MA(U42383) FIN 13 |
MA(U09138) PPAR γ2 | MA(M65287) ActR |
MA(M62867) MSY-1 | MA (K01700) p53 |
MA(U20282) SPBP | MA (U28789) PACT |
MA (D31966) RNA polymerase I 40 kDa subunit | MA (X59728) gas5 |
MA (X67083) Chop-10 | MA (X54149) MyD118 |
MA (X61800) C/EBP δ | MA (L02914) Aquaporin |
MA (X62940) TSC-22 | MA (M86736) Acrogranin |
MA (L03279) CBF | ECM/Adhesion |
MA (D43643) YL-1 | MA(M15525) Laminin B1 |
RNA processing | MA(M65287) ActR |
DD(AB017020) HnRNP D-like/JKTBP (x2) | MA(L08235) Clusterin |
MA(U11274) AUF1 | DD(X040170) SPARC |
MA(AA408185) SFRS7 | MA(D14340) ZO-1 |
MA(X66091) ASF | DD(U75916) ZO-2 |
MA(L15447) Rnu1a-1 | MA (X56123) Talin |
MA(U48737) PRP4m | MA (L02918) procollagen type V alpha 2 |
MA(AF017153) mDEAH9 | MA (J04694) α-1 type IV collagen |
MA (X80232) SIG41 | MA (J04695) α-2 type IV collagen |
MA (U70315) U1 snRNP- C | MA (L29454) Fibrillin |
Calcium binding | MA (Z30970) TIMP-3 |
MA(M37761) Calcyclin | MA (AA184551) Cadherin-11 |
MA(D86214) Ca2+ dep. activated. Prot. for secretion | MA (D90362) CAP102/alpha catenin |
MA(X83934) Ryanodine receptor type 3 | Antigen presentation |
DD(X04017) SPARC | DD (M35244) MHC-1b H2-TL-T10-129 |
MA (U81829) Calumenin | MA (U10090) C57BL/6 Ly-49D-GE antigen |
MA (L29454) Fibrillin | DD,MA (AF110520) MHC class II |
Cytoskeleton organization | DD (X04653) T-cells activating protein (TAP) |
MA(L20509) Matricin | MA (U60087) TAP2-d |
Nβ-actin | MA (X62742) Ma |
DD(AF064236.1) Smoothelin large isoform L2 | MA (U35323) H2-M α, H2-M β2, H2-M β1, Lmp2 |
MA (X56123) Talin | MA (U65636) beta proteasome subunit (Lmp3) |
MA (Z31553) Cctz (Chaperonin containing TCP-1 β z) | MA U22031) 20S proteasome subunit (Lmp7) |
MA (D49382) Nedd5 (Septin) | MA (L11613) proteasome (lmp2) |
MA (W08453) Destrin | MA (D85561) proteasome subunit MECL1 |