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Table 4 Functional clustering of deregulated genes in the arthritic synovial fibroblasts

From: Functional analysis of an arthritogenic synovial fibroblast

Stress response Protein synthesis
DD(M34561) Hsp70 DDU89417) Ribosomal protein L3 (x3)
DD(AF170920) HSPC030 DD(X15013.1) Ribosomal protein L7a (x3)
DD(AA240130) EST~GMP reductase Reductase MA(U93862) Ribosomal protein L41
DD(U93231.1) Aldose MA(AA048927) Aminoacyl-tRNA synthetase
DD(NM010239) Ferritin heavy chain DD(AF081140) Homologue to eIF6/integrin b4 int. prot.
Energy production MA(U63323) Translation initiation factor (Eif4g2)
DD,.MA(U53584) Mt DNA polymerase γ MA (AA408104) Translational initiation factor (eIF-2) α
DD(M22756) NADH dehydrogenase S2 MA (AA254996) Alanyl-tRNA synthetase
DD(AF100726) NADH dehydrogenase S4 Protein degardation
DD(AF058955) Succinyl-CoA synthetase β MA (U19854) ubiquitinating enzyme E2-20K
DD (AF159396.1) Mt. Cytochrome b MA (X97042) UBcM4
MA (X01756) Cytochrome c (MC1) MA (AA198790)ubiquinol-cytochrome c reductase (6.4)
MA (U03283) C3H cytochrome P450 (Cyp1b1) MA (AA237529)ubiquinol-cytochrome c reductase (7.2)
Transcription Growth control
DD(NM007241) EAP330 of ELL DD, MA(U42383) FIN 13
MA(U09138) PPAR γ2 MA(M65287) ActR
MA(M62867) MSY-1 MA (K01700) p53
MA(U20282) SPBP MA (U28789) PACT
MA (D31966) RNA polymerase I 40 kDa subunit MA (X59728) gas5
MA (X67083) Chop-10 MA (X54149) MyD118
MA (X61800) C/EBP δ MA (L02914) Aquaporin
MA (X62940) TSC-22 MA (M86736) Acrogranin
MA (L03279) CBF ECM/Adhesion
MA (D43643) YL-1 MA(M15525) Laminin B1
RNA processing MA(M65287) ActR
DD(AB017020) HnRNP D-like/JKTBP (x2) MA(L08235) Clusterin
MA(U11274) AUF1 DD(X040170) SPARC
MA(AA408185) SFRS7 MA(D14340) ZO-1
MA(X66091) ASF DD(U75916) ZO-2
MA(L15447) Rnu1a-1 MA (X56123) Talin
MA(U48737) PRP4m MA (L02918) procollagen type V alpha 2
MA(AF017153) mDEAH9 MA (J04694) α-1 type IV collagen
MA (X80232) SIG41 MA (J04695) α-2 type IV collagen
MA (U70315) U1 snRNP- C MA (L29454) Fibrillin
Calcium binding MA (Z30970) TIMP-3
MA(M37761) Calcyclin MA (AA184551) Cadherin-11
MA(D86214) Ca2+ dep. activated. Prot. for secretion MA (D90362) CAP102/alpha catenin
MA(X83934) Ryanodine receptor type 3 Antigen presentation
DD(X04017) SPARC DD (M35244) MHC-1b H2-TL-T10-129
MA (U81829) Calumenin MA (U10090) C57BL/6 Ly-49D-GE antigen
MA (L29454) Fibrillin DD,MA (AF110520) MHC class II
Cytoskeleton organization DD (X04653) T-cells activating protein (TAP)
MA(L20509) Matricin MA (U60087) TAP2-d
Nβ-actin MA (X62742) Ma
DD(AF064236.1) Smoothelin large isoform L2 MA (U35323) H2-M α, H2-M β2, H2-M β1, Lmp2
MA (X56123) Talin MA (U65636) beta proteasome subunit (Lmp3)
MA (Z31553) Cctz (Chaperonin containing TCP-1 β z) MA U22031) 20S proteasome subunit (Lmp7)
MA (D49382) Nedd5 (Septin) MA (L11613) proteasome (lmp2)
MA (W08453) Destrin MA (D85561) proteasome subunit MECL1
  1. Numbers in parentheses refer to accession numbers; superscript prefixes indicate the method of gene selection, as follows: DD, differential display; MA, microarrays; N, Northern blot. Shading denotes down-regulated genes.