Arthritis Research & Therapy

Table 1 Reactivity of serum samples to the CD69 and to fragments of LRP2

From: Autoantibodies to low-density-lipoprotein-receptor-related protein 2 (LRP2) in systemic autoimmune diseases

		Recombinant protein
			LRP2
Disease	No. of sera	CD69	F2	F3	F4	F5	F6	F7
RA (n = 47)
	6	-	-	+	-	-	-	+
	6	-	-	+	-	-	-	-
	4	+	+	+	+	+	+	+
	3	+	-	+	+	-	+	+
	3	+	-	+	-	-	-	+
	2	-	+	+	-	-	+	+
	2	+	+	+	-	-	-	-
	2	-	-	+	-	+	-	+
	2	-	-	+	+	-	-	-
	2	-	-	+	-	-	+	-
	2	-	-	-	+	-	-	-
	1	+	-	+	+	+	+	+
	1	+	-	+	-	+	-	+
	1	-	-	+	-	+	+	+
	1	-	-	+	+	-	+	-
	1	-	-	-	+	+	+	-
	1	-	-	-	-	+	+	+
	1	-	-	+	-	+	-	-
Total sera	41
Positive reactions [No. (%)]		14 (34)	8 (20)	37 (90)	14 (34)	12 (29)	16 (39)	24 (58)
SLE (n = 30)
	6	-	-	-	-	+	-	-
	2	-	-	-	-	+	+	-
	2	-	-	-	+	-	-	-
	1	+	+	+	-	+	-	+
	1	-	-	-	-	-	-	+
Total sera	12
Positive reactions [No. (%)]		1 (8)	1 (8)	1 (8)	2 (17)	9 (75)	2 (17)	2 (17)
SSc (n = 20)
	2	-	+	-	-	-	-	-
	2	-	-	+	-	-	-	-
	2	-	+	+	-	-	-	-
	1	-	-	+	-	-	-	+
Total sera	7
Positive reactions [No. (%)]		0 (0)	4 (57)	5 (71)	0 (0)	0 (0)	0 (0)	1 (14)
OA (n = 20)
	1	+	+	+	-	-	-	+
	1	-	-	+	-	-	-	+
	1	-	-	-	-	-	+	-
Total sera	3
Positive reactions [No. (%)]		1 (33)	1 (33)	2 (67)	0 (0)	0 (0)	1 (33)	2 (67)
None (healthy controls) (n = 75)
	2	-	-	+	-	-	-	+
	2	-	-	-	-	+	-	-
Total sera	4
Positive reactions [No. (%)]		0 (0)	0 (0)	2 (50)	0 (0)	2 (50)	0 (0)	2 (50)

LRP2 = low-density-lipoprotein-receptor-related protein 2; OA = osteoarthritis; RA = rheumatoid arthritis; SLE = systemic lupus erythematosus; SSc = systemic sclerosis.

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