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Table 1 Reactivity of serum samples to the CD69 and to fragments of LRP2

From: Autoantibodies to low-density-lipoprotein-receptor-related protein 2 (LRP2) in systemic autoimmune diseases

   Recombinant protein
    LRP2
Disease No. of sera CD69 F2 F3 F4 F5 F6 F7
RA (n = 47)         
  6 - - + - - - +
  6 - - + - - - -
  4 + + + + + + +
  3 + - + + - + +
  3 + - + - - - +
  2 - + + - - + +
  2 + + + - - - -
  2 - - + - + - +
  2 - - + + - - -
  2 - - + - - + -
  2 - - - + - - -
  1 + - + + + + +
  1 + - + - + - +
  1 - - + - + + +
  1 - - + + - + -
  1 - - - + + + -
  1 - - - - + + +
  1 - - + - + - -
Total sera 41        
Positive reactions [No. (%)]   14 (34) 8 (20) 37 (90) 14 (34) 12 (29) 16 (39) 24 (58)
SLE (n = 30)         
  6 - - - - + - -
  2 - - - - + + -
  2 - - - + - - -
  1 + + + - + - +
  1 - - - - - - +
Total sera 12        
Positive reactions [No. (%)]   1 (8) 1 (8) 1 (8) 2 (17) 9 (75) 2 (17) 2 (17)
SSc (n = 20)         
  2 - + - - - - -
  2 - - + - - - -
  2 - + + - - - -
  1 - - + - - - +
Total sera 7        
Positive reactions [No. (%)]   0 (0) 4 (57) 5 (71) 0 (0) 0 (0) 0 (0) 1 (14)
OA (n = 20)         
  1 + + + - - - +
  1 - - + - - - +
  1 - - - - - + -
Total sera 3        
Positive reactions [No. (%)]   1 (33) 1 (33) 2 (67) 0 (0) 0 (0) 1 (33) 2 (67)
None (healthy controls) (n = 75)         
  2 - - + - - - +
  2 - - - - + - -
Total sera 4        
Positive reactions [No. (%)]   0 (0) 0 (0) 2 (50) 0 (0) 2 (50) 0 (0) 2 (50)
  1. LRP2 = low-density-lipoprotein-receptor-related protein 2; OA = osteoarthritis; RA = rheumatoid arthritis; SLE = systemic lupus erythematosus; SSc = systemic sclerosis.