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Table 2 Percentage of synovial cells expressing HIF-1α and HIF-2α proteins in normal, rheumatoid, and osteoarthritic synovium

From: Upregulated hypoxia inducible factor-1α and -2α pathway in rheumatoid arthritis and osteoarthritis

  Normal (n= 22) OA (n = 34) RA (n = 22)
  HIF-1α HIF-2α HIF-1α HIF-2α HIF-1α HIF-2α
Minimum 0.00 0.00 20.00 0.00 10.00 10.00
25th percentile 0.00 0.00 40.00 30.00 35.00 25.00
Median 0.00 0.00 60.00 50.00 50.00 60.00
75th percentile 10.00 0.00 90.00 90.00 75.00 80.00
Maximum 20.00 10.00 100.0 100.0 80.00 80.00
Mean 5.45 1.81 63.53 55.29 50.91 50.91
Standard deviation 9.11 3.94 29.12 32.50 24.08 28.10
Standard error 1.94 0.84 4.99 5.57 5.13 5.99
Lower 95% CI 1.41 0.06 53.37 43.96 40.23 39.55
Upper 95% CI 9.49 3.56 73.69 66.63 61.59 63.37
  1. CI, confidence interval; HIF, hypoxia inducible factor; OA, osteoarthritis; RA, rheumatoid arthritis.