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Table 4 Correlation of HIF-1α and HIF-2α expression with MVD, VEGF/KDR activated MVD, and PD-ECGF expression by synovial lining and stromal cells, and with bcl-2 expression, in the rheumatoid and osteoarthritic synovium

From: Upregulated hypoxia inducible factor-1α and -2α pathway in rheumatoid arthritis and osteoarthritis

  HIF-1α HIF-2α
  Low High P Low High P
Rheumatoid arthritis       
   Standard MVD 57 ± 10 63 ± 7 0.16 61 ± 6 59 ± 10 0.63
   Activated MVD 27 ± 12 34 ± 10 0.14 31 ± 10 31 ± 12 0.97
   % PD-ECGF lin. cells 50 ± 13 55 ± 24 0.57 50 ± 30 54 ± 12 0.65
   % PD-ECGF str. cells 82 ± 10 81 ± 9 0.95 80 ± 10 82 ± 9 0.51
   % bcl-2 4 ± 8 2 ± 4 0.54 0 ± 0 5 ± 7 -
Osteoarthritis       
   Standard MVD 58 ± 10 73 ± 18 0.01 68 ± 23 66 ± 11 0.71
   Activated MVD 15 ± 3 18 ± 4 0.01 16 ± 3 17 ± 4 0.46
   % PD-ECGF lin. cells 51 ± 14 68 ± 21 0.01 55 ± 18 66 ± 21 0.14
   % PD-ECGF str. cells 30 ± 17 49 ± 26 0.01 34 ± 18 47 ± 21 0.13
   % bcl-2 5 ± 8 32 ± 25 0.0007 18 ± 25 25 ± 23 0.46
  1. HIF, hypoxia inducible factor; lin., synovial lining; MVD, microvessel density; OA, osteoarthritis; PD-ECGF, platelet-derived endothelial cell growth factor; RA, rheumatoid arthritis; str., stromal.