Table 4 Correlation of HIF-1α and HIF-2α expression with MVD, VEGF/KDR activated MVD, and PD-ECGF expression by synovial lining and stromal cells, and with bcl-2 expression, in the rheumatoid and osteoarthritic synovium
From: Upregulated hypoxia inducible factor-1α and -2α pathway in rheumatoid arthritis and osteoarthritis
HIF-1α | HIF-2α | |||||
|---|---|---|---|---|---|---|
Low | High | P | Low | High | P | |
Rheumatoid arthritis | ||||||
Standard MVD | 57 ± 10 | 63 ± 7 | 0.16 | 61 ± 6 | 59 ± 10 | 0.63 |
Activated MVD | 27 ± 12 | 34 ± 10 | 0.14 | 31 ± 10 | 31 ± 12 | 0.97 |
% PD-ECGF lin. cells | 50 ± 13 | 55 ± 24 | 0.57 | 50 ± 30 | 54 ± 12 | 0.65 |
% PD-ECGF str. cells | 82 ± 10 | 81 ± 9 | 0.95 | 80 ± 10 | 82 ± 9 | 0.51 |
% bcl-2 | 4 ± 8 | 2 ± 4 | 0.54 | 0 ± 0 | 5 ± 7 | - |
Osteoarthritis | ||||||
Standard MVD | 58 ± 10 | 73 ± 18 | 0.01 | 68 ± 23 | 66 ± 11 | 0.71 |
Activated MVD | 15 ± 3 | 18 ± 4 | 0.01 | 16 ± 3 | 17 ± 4 | 0.46 |
% PD-ECGF lin. cells | 51 ± 14 | 68 ± 21 | 0.01 | 55 ± 18 | 66 ± 21 | 0.14 |
% PD-ECGF str. cells | 30 ± 17 | 49 ± 26 | 0.01 | 34 ± 18 | 47 ± 21 | 0.13 |
% bcl-2 | 5 ± 8 | 32 ± 25 | 0.0007 | 18 ± 25 | 25 ± 23 | 0.46 |