TY - JOUR AU - Hirohata, Shunsei AU - Kikuchi, Hirotoshi PY - 2003 DA - 2003/04/02 TI - Behçet's disease JO - Arthritis Res Ther SP - 139 VL - 5 IS - 3 AB - Behçet's disease is characterized by recurrent aphthous stomatitis, uveitis, genital ulcers, and skin lesions. The role of the HLA-B*51 gene has been confirmed in recent years, although its contribution to the overall genetic susceptibility to Behçet's disease was estimated to be only 19%. The production of a variety of cytokines by T cells activated with multiple antigens has been shown to play a pivotal role in the activation of neutrophils. As regards the treatment, anti-tumor necrosis factor alpha therapy has been shown to be effective for mucocutaneous symptoms as well as for sight-threatening panuveitis, although a randomized, controlled trial is required. SN - 1478-6354 UR - https://doi.org/10.1186/ar757 DO - 10.1186/ar757 ID - Hirohata2003 ER -