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Table 2 Extent to which known genetic associations can account for west African/European difference in risk for systemic lupus erythematosus

From: Risk for rheumatic disease in relation to ethnicity and admixture

   Risk ratio Allele frequencies controls  
Locus Alleles Eur Afr Eur Afr Population risk ratio*
Loci within the HLA region       
HLA-DR [20,21,65] DRB1*0301 (DRw17) 2 1.3 0.12 0.14 1.0
  DRB1*0302 (DRw18)      
  (HLA-DR2)      
  DRB1*1501 (DRw15) 2.4 2.7 0.13 0.14 1.0
  DRB1*1503 (DRw15)      
  (HLA-DR3)      
HLA-B [18] *0801 (B8) 1.8 1.4 0.12 0.03 0.9
C4A [20] *Q0 (Null) 3.0 3.6 0.1 0.07 0.9
TNF-α [27] -308A 3.8 2.7 0.12 0.04 0.9
HSP70-2 [25] 8.5-kilobase Pst1 2.1 2.6 0.36 0.61 1.2
Loci outside the HLA region       
Mannose-binding protein (54) [28,66] GAC 1.6 1.4 0.19 0.11 1.0
FCγ RIIa [29] R131 1.3 1.8 0.51 0.48 1.0
  1. *The population risk ratio has been calculated using the mean of the genotypic risk ratio in Europeans and the genotypic risk ratio in Africans, calculating genotype frequencies assuming Hardy–Weinberg equilibrium. Risk ratios have been calculated by averaging frequencies of HLA-DR2 and HLA-DR3 across studies [21,65]. HLA, human leucocyte antigen; HSP, heat shock protein; TNF, tumour necrosis factor.