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Table 4 Spearman rank correlations of changes in laboratory results from baseline to 24 months in postmenopausal women with rheumatoid arthritis who were given HRT

From: Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1

Test TNF-α IL-1Ra IL-6 sIL-6R IGF-1 ESR Estradiol BMD total hip BMD lumbar spine
Serum TNF-α (pg/ml) 0.303** 0.108 0.245* -0.258* 0.310** -0.263* 0.169 -0.132
Serum IL-1Ra (pg/ml) 0.303** 0.313** 0.050 -0.222 0.122 0.012 0.075 -0.126
Serum IL-6 (pg/ml) 0.108 0.313** 0.041 -0.061 0.421*** 0.188 0.081 0.078
Serum sIL-6R (pg/ml) 0.245* 0.050 0.041 -0.137 0.119 -0.263* -0.132 -0.278*
Serum IGF-1 (ng/ml) -0.258* -0.222 -0.061 -0.137 -0.250* 0.179 0.200 0.195
ESR (mm) 0.310** 0.122 0.421*** 0.119 -0.250* -0.079 -0.092 -0.145
Serum estradiol (pmol/l) -0.263* 0.012 0.188 -0.263* 0.179 -0.079 0.491*** 0.483***
  1. *P < 0.05, **P < 0.01, ***P < 0.001. BMD = bone mineral density; ESR = erythrocyte sedimentation rate; IGF-1 = insulin-like growth factor 1; IL-1Ra = IL-1-receptor antagonist; sIL-6R = soluble IL-6 receptor; TNF-α = tumor necrosis factor α.