From: Wegener's granulomatosis: current and upcoming therapies
Is the disease active? | Differentiate active disease from: |
 |    Chronic sequelae of disease |
 |    Medication toxicity |
 |    Other diseases (in particular, infection) |
How severe is the active disease? | Immediately life-threatening disease necessitates initial treatment with cyclophosphamide and glucocorticoids |
What organ sites are being affected? | Certain sites of organ involvement, particularly subglottic stenosis, may not require or may not respond to systemic immunosuppressive therapy |
What is the data on different therapeutic regimens? | What is the data for the regimen being considered (see Table 3)? |
 |    Has the regimen improved survival? |
 |    What is the likelihood of inducing remission? |
 |    What is the relapse rate? |
 |    What are the known toxicities? |
Consideration of individual patient factors | History of medication toxicity |
 | Contraindications to certain medications |
 | Presence of previous organ damage |
 | Relapse history with past treatment regimens |
 | Age |
 | Gender |