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Table 2 Expression in vivo of tristetraprolin in volunteers

From: Regulation and localization of endogenous human tristetraprolin

Volunteer no.

 

Neutrophils

Lymphocytes

Monocytes

1

Baseline

16.5 (1.2)

18.8 (1.0)

15.6 (1.6)

 

Peak

54.9 (2.0)

90.4 (8.8)

18.9 (2.4)

2

Baseline

15.6 (1.2)

9.9 (1.0)

23.2 (2.0)

 

Peak

17.1 (3.6)

13.1 (1.2)

40.8 (4.3)

3

Baseline

9.7 (8.2)

4.2 (0.5)

20.8 (1.3)

 

Peak

20.8 (1.4)

9.4 (2.3)

62.0 (29.0)

4

Baseline

13.6 (1.1)

6.0 (0.6)

16.6 (1.7)

 

Peak

17.5 (1.1)

19.1 (1.8)

47.2 (1.6)

  1. Values are mean milliequivalents of soluble fluorescein (SE) (in thousands). Human subjects were infused with a bolus dose of lipopolysaccharide at T = 0. Blood was drawn at specific times before and after infusion, and the leukocytes were purified by dextran sedimentation. Expression of tristetraprolin was determined by flow cytometry.