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Table 2 Determination of serum matrix metalloproteinase and tissue inhibitor of metalloproteinase concentrations

From: Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis

  Normal range RA (n = 45) Non-RA (n = 21) Erosions (n = 12) No erosions (n = 54)
MMP-1 (ng/ml) 0 4.0 ± 5.5 1.9 ± 2.7 7.1 ± 6.7* 2.5 ± 4.0
MMP-2 (total; ng/ml) 156-254 115 ± 50 112 ± 28 103 ± 25 116 ± 47
MMP-2 (active) N/A 15 ± 15 15 ± 14 10 ± 8 16 ± 13
MMP-9 (total; ng/ml) 13-61 44 ± 32 49 ± 34 40 ± 35 46 ± 32
MMP-9 (active) N/A 2.3 ± 3.3 3.3 ± 3.6 2.8 ± 3.5 1.6 ± 3.3
TIMP-1 (μ g/ml) 0.3-0.5 1.6 ± 0.7 2.0 ± 0.9 1.5 ± 0.6 1.7 ± 0.8
TIMP-2 (ng/ml) 29-108 105 ± 166 72 ± 134 140 ± 168 85 ± 54
CRP (mg/dl) <0.4 2.0 ± 3.9 2.2 ± 2.4 3.2 ± 3.2* 1.9 ± 2.8
  1. Values are expressed as mean ± standard deviation of serum matrix metalloproteinase (MMP) levels measured in 66 patients. Comparison groups were divided into rheumatoid arthritis (RA) and non-RA patients, and subsequently into patients with erosive and nonerosive disease. Erosions were defined as definite erosions in more than one joint (see Patients and method). Normal values provided by the manufacturer of the ELISA kit. Normal values were not available for the assays for active MMP-2 and MMP-9. *P <0.01. crp, c-reactive protein; timp, tissue inhibitor of metalloproteinase.