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Table 3 Immunohistologic and zymographic expression of matrix metalloproteinases in synovial tissues from patients with recent onset ofArthritis

From: Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis

  RA (n = 21) Non-RA (n = 7) Normal tissue (n = 4)
Immunohistology    
    Composite inflammatory index (0-4) 1.5± 0.5 1.7± 0.9 0± 0.1††
    MMP-2 50 ± 30 78 ± 45 0††
    MMP-14 8.4 ± 5** 3.7 ± 4 0††
    TIMP-2 25 ± 12 39 ± 9* 0††
    MMP-9 10.9 ± 6 7.4 ± 7 1 ± 0††
Gelatinolytic activity    
    Active MMP-2 activity (ng/mg) 2.6 ± 2.7 1.3 ± 1.1 1.3 ± 0.5
    Total MMP-2 activity (ng/mg) 13.6 ± 9.6 8.6 ± 3.5 5.7 ± 0.7
    MMP-9 activity (ng/mg) 18.0 ± 28.9 60.3 ± 136 4.0 ± 0.7
  1. For definition of 'composite index', refer to the Patients and method section. *P < 0.05, **P < 0.01, versus nonrheumatoid arthritis (ra) patients; P < 0.05, P < 0.01, versus normal volunteers. mmp, matrix metalloproteinase; timp, tissue inhibitor of metalloproteinase.