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Table 2 The 2 × 2 analyses [9] of the data in Table 1

From: Association of MHC and rheumatoid arthritis: HLA-DR4 and rheumatoid arthritis - studies in mice and men

Test Comparison a b c d Odds ratio Fisher's P value
DQA-RA   179 58 146 160 3.4 3E-11
association        
SE association   172 65 127 179 3.7 3E-13
DQA-RA association        
in SE-positive ++ vs -+ 172 0 127 0 ND ND
DQA-RA association        
in SE-negative +- vs-- 7 58 19 160 1.1 NS
SE association in        
DQ-RA-positive ++ vs +- 172 7 127 19 3.5 0.0024; p c = 0.029
SE association in        
DQ-RA-negative -+ vs-- 0 58 0 160 ND ND
  1. ND, Not defined; NS, not significant; P c, corrected Pvalue; a and b, numbers of patients with and without marker in question; cand d, numbers of controls with and without marker in question.