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Table 3 Diagnostic value of individual autoantibodies for rheumatoid arthritis

From: Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset

  Sensitivity Specificity PPV NPV Accuracy
RF 0.66 0.87 0.80 0.76 0.78
AFA 0.33 0.93 0.79 0.63 0.66
Anti-Sa 0.22 0.98 0.88 0.61 0.64
Anti-CCP 0.41 0.91 0.78 0.66 0.69
AKA 0.26 0.84 0.56 0.58 0.58
RF+ and one or more* 0.50 0.96 0.90 0.70 0.75
RF- and one or more* 0.31 0.73 0.26 0.77 0.63
  1. * Includes antifilaggrin antibody (AFA), anti-Sa, cyclic citrullinated peptide (anti-CCP) and antikeratin antibody (AKA). PPV, positive predictive value; NPV, negative predictive value; RF, rheumatoid factor.