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Table 4 Sa is associated with severe rheumatoid arthritis (RA)

From: Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset

  Sa+ RA Sa- RA RF+ RA RF- RA SE+ RA SE- RA
  (n=23) (n=83) (n=70) (n=36) (n=62) (n=44)
Male (%) 14 (61)* 23 (28) 27 (39) 10 (28) 24(39) 13 (30)
Age 48 ± 15 46 ± 13 47 ± 12 44 ± 15 49 ± 13* 42 ± 13
Duration of symptoms (weeks) 36 ± 25 30 ± 18 33 ± 17 29 ± 24 32 ± 15 31 ± 25
Initial visit       
   Swollen joints 18 ± 12* 13 ± 9 13 ± 9 16 ± 10 13 ± 9 14 ± 11
   Nodules 1(4) 5 (6) 5 (7) 1 (3) 5(8) 1 (2)
   CRP (mg/dl) 2.6 ± 3* 1.6 ± 1.4 1.9 ± 1.8 1.9 ± 2.1 1.7 ± 1.5 2.1 ± 2.4
   On DMARDs (%) 11 (48) 31 (37) 28 (40) 14 (39) 24 (39) 18 (41)
   On prednisone (%) 12 (52) 29 (35) 25 (36) 16 (44) 26 (42) 15 (34)
   Multiple erosions (%) 7 (30) 12 (14) 12 (17) 7 (19) 12 (19) 7 (16)
One year visit       
   Swollen joints 8 ± 9 8 ± 10 9 ± 11 7 ± 7 10 ± 11* 5 ± 6
   CRP (mg/dl) 1.1 ± 0.7 1.2 ± 1.8 1.3 ± 1.9 0.9 ± 0.5 1.4 ± 2.1 0.9 ± 0.3
   Number of DMARDs 1.4 ± 0.8* 0.9 ± 0.7 0.9 ± 0.7 1.0 ± 0.8 0.9 ± 0.7 1.1 ± 0.8
   Prednisone (mg/day) 4.8 ± 6.0* 1.8 ± 3.3 2.7 ± 4.8 2.0 ± 2.5 2.7 ± 4.0 2.1 ± 3.9
   Multiple erosions (%) 12 (60)* 27 (33) 24 (34) 14 (39) 25 (42) 13 (30)
   Inactive disease (%) 0 9 (12) 3 (4) 6 (17) 4 (7) 5 (11)
  1. Independent comparisons are made between Sa+ and Sa- RA, RF+ and RF- RA, SE+ and SE- RA. *P<0.05.One hundred and two out of 106 (96%) of the patients had 1 year radiographs available for analysis. Multiple erosions included all patients with two or more erosions that involved at least two separate joint areas. RF, Rheumatoid factor; SE, shared epitope; CRP, C-reactive protein; DMARD, disease modifying antirheumatic drug.