Table 2 Effects of osteoprotegerin in animal models of arthritis
| Â | Kong et al. [36] | Redlich et al. [14] | Romas et al. [37] |
|---|---|---|---|
Arthritis model | Adjuvant arthritis | hTNFtg | Collagen-induced arthritis |
Species | Rat | Mouse | Rat |
Dose | 1 mg/kg/day | 6.4 mg/kg/day | 3 mg/kg/day |
Start | Onset of symptoms | Onset of symptoms | Onset of symptoms |
Duration | 7 days | 35 days | 5 days |
Effect on inflammation | No | No | No |
Effect on cartilage damage | Yes | No | Milda |
Effect on bone erosion | Yes | -56% | -60% |
Effect on osteoclast count | -85% | -70%b,c | -75%c |
Effect on osteoporosis | Yes | Yes | Not assessed |