Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts

Table 1 SSc patient and healthy volunteer characteristics

	SSc	Diffuse SSc	Limited SSc	Healthy subjects
	(n = 60)	(n = 36)	(n = 24)	(n = 38)
Age (years)	57.0 ± 1.4^a	55.7 ± 1.8	58.2 ± 2.2	44.3 ± 2.4
Sex	F46/M14	F27/M9	F21/M3	F26/M12
Disease duration (years)	8.7 ± 1.2	5.4 ± 1.0	13.8 ± 2.2	N.A.^b
mRSS^c	13.4 ± 1.5	18.5 ± 2.0	5.3 ± 0.8	N.A.
Raynaud’s	60	36	24	N.A.
Early disease^d	31	24	7	N.A.
Deceased	1	0	1	N.A.
Digital ulcers	18	14	4	N.A.
Teleangectasias	38	21	17	N.A.
Gastrointestinal disease	53	31	20	N.A.
ILD^e	30	21	8	N.A.
PAH^f	18	8	9	N.A.
Renal involvement	5	3	2	N.A.

^aMean ± SEM; ^bN.A. = Not applicable; ^cmRSS = modified Rodnan skin score (0–51); ^dEarly disease = less than 5 years; ^eInterstitial lung disease; ^fPulmonary arterial hypertension.

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