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Table 1 Selected associations found in cohorts 1 and 2

From: Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis

Gene

rs number

Chromosome

Position

Cohort 1P-value

Cohort 1 odds ratio (95% CI)

Cohort 2P-value

Cohort 2 odds ratio (95% CI)

Anti-CCP

Anti-CCP - all patients

PTPN22

rs2476601

1

114179091

0.119

1.235 (0.948, 1.617)

0.104

1.519 (0.920, 2.569)

MICA

rs2523451

6

31477130

0.062

1.382 (0.984, 1.938)

0.035

1.707 (1.039, 2.795)

HLA-DQB1

rs6457617

6

32771829

2.22 × 10−16

4.232 (2.998, 6.008)

0.131

2.028 (0.803, 4.911)

CDK6

rs42041

7

92084680

0.017

1.368 (1.056, 1.777)

0.162

1.404 (0.874, 2.285)

Anti-CCP- HLA-DRB1*04 patients

PTPN22

rs2476601

1

114179091

0.018

1.67 (1.090, 2.628)

0.19

1.751 (0.765, 4.415)

Anti-CCP - Non- HLA-DRB1*04 patients

PADI4

rs2240340

1

17535226

0.012

1.718 (1.128, 2.625)

0.15

1.627 (0.838, 3.176)

CDK6

rs42041

7

92084680

0.001

1.831 (1.265, 2.660)

0.055

1.909 (0.987, 3.772)

Citrullinated-vimentin

Citrullinated-vimentin - all patients

PTPN22

rs2476601

1

114179091

0.048

1.272 (1.002, 1.614)

0.021

1.691 (1.083, 2.667)

MICA

rs2523451

6

31477130

0.005

1.595 (1.151, 2.221)

0.009

1.818 (1.162, 2.851)

HLA-DQB1

rs6457617

6

32771829

2.36 × 10−10

3.417 (2.285, 5.266)

0.001

4.948 (1.890, 15.652)

HLA-DPB1

rs2064476

6

33181300

0.19

1.636 (0.787, 3.594)

0.028

3.228 (1.132, 10.682)

TRAF1

rs3761847

9

122730060

0.088

1.254 (0.967, 1.631)

0.171

1.406 (0.863, 2.289)

Citrullinated-vimentin - HLA-DRB1*04 patients

PTPN22

rs2476601

1

114179091

0.022

1.437 (1.054, 1.967)

0.04

1.912 (1.029, 3.672)

MICA

rs2523451

6

31477130

0.085

1.495 (0.945, 2.362)

0.133

1.639 (0.858, 3.106)

Citrullinated-vimentin - non- HLA-DRB1*04 patients

HLA-DQB1

rs6457617

6

32771829

0.161

1.387 (0.880, 2.233)

0.042

2.814 (1.034, 9.151)

CEP-1

CEP-1- all patients

PTPN22

rs2476601

1

114179091

0.016

1.339 (1.055, 1.702)

0.078

1.475 (0.957, 2.279)

HLA-DQB1

rs6457617

6

32771829

5.11 × 10−11

3.213 (2.242, 4.676)

0.166

1.896 (0.772, 5.144)

PRKCQ

rs4750316

10

6433266

0.133

1.204 (0.945, 1.534)

0.004

1.86 (1.220, 2.849)

HTR2A

rs1328674

13

46339708

0.187

1.33 (0.871, 2.051)

0.115

1.924 (0.854, 4.546)

CEP-1 - HLA-DRB1*04 patients

CIITA

rs6416647

16

10873098

0.011

1.525 (1.099, 2.121)

0.194

1.431 (0.833, 2.468)

CEP-1 - non- HLA-DRB1*04 patients

HLA-DQB1

rs2064476

6

33181300

0.002

1.894 (1.268, 2.865)

0.155

3.8 (0.656, 97.488)

PRKCQ

rs4750316

10

6433266

0.106

1.379 (0.934, 2.035)

0.003

2.919 (1.446, 5.965)

CitC1 III

CitC1 III - all patients

MMEL1

rs3890745

1

2543484

0.158

1.319 (0.899, 1.959)

0.122

1.883 (0.850, 4.634)

CDK6

rs42041

7

92084680

0.166

1.181 (0.933, 1.495)

0.044

1.549 (1.012, 2.372)

CitC1 - HLA-DRB1*04 patients

TNFAIP3

rs6920220

6

138048197

0.067

1.796 (0.960, 3.504)

0.052

3.254 (0.991, 15.257)

CitC1 III - non- HLA-DRB1*04 patients

CDK6

rs42041

7

92084680

0.038

1.502 (1.023, 2.210)

0.051

1.99 (0.997, 3.988)

  1. P-values in bold represent the most significant associations with values <0.05 for both cohorts.
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Arthritis Research & Therapy

ISSN: 1478-6362

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