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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration

Figure 4

Cytokine regulation of neuropeptides substance P and CGRP within human nucleus pulposus cells, SH-SY5Y and HDMEC cells. Substance P (SP) and calcitonin gene-related peptide (CGRP) mRNA expression in human nucleus pulposus (NP) cells following stimulation with interleukin (IL)-1β (A1), tumour necrosis factor alpha (TNFα) (B) and IL-6 (C). SP protein was also determined in human NP cells following stimulation with IL-1β (A2). SP and CGRP mRNA expression in SH-SY5Y neuronal cells following cytokine stimulation (D). SP mRNA was not expressed by human dermal microvascular endothelial cells (HDMEC)-1 and cytokines did not significantly regulate CGRP mRNA expression (E). *Statistical significance: P ≤ 0.05. GAPDH, glyceraldehyde-3-phosphate dehydrogenase.

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Arthritis Research & Therapy

ISSN: 1478-6362

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