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Table 2 Symptoms, associated disorders and prescribed drugs

From: Effect of one year of a gluten-free diet on the clinical evolution of irritable bowel syndrome plus fibromyalgia in patients with associated lymphocytic enteritis: a case-control study

Symptoms, n (%) All cases n = 97 Normal mucosa (Marsh stage 0) n = 39 Lymphocytic enteritis (Marsh stage 1) n = 58 P
Widespread soft-tissue pain 97 (100) 39 (100) 58 (100) 1.000
Digestive complaints 97 (100) 39 (100) 58 (100) 1.000
Fatigue 88 (91) 35 (90) 53 (91) 0.932
Sleep disturbances 81 (83) 29 (74) 52 (89) 0.087
Anxiety/depression 64 (66) 22 (56) 42 (72) 0.158
Skin problems 48 (49) 20 (51) 28 (48) 0.934
Foggy mind 34 (35) 14 (36) 20 (34) 0.941
Urinary urgency 28 (29) 10 (26) 18 (31) 0.729
Balance problems/dizziness 27 (28) 10 (26) 17 (29) 0.869
Chronic headaches 26 (27) 5 (13) 21 (36) 0.021
Joint stiffness 25 (26) 9 (23) 16 (28) 0.794
Paraesthesias 23 (24) 9 (23) 14 (24) 0.902
Associated disorders , n (%)     
Osteoporosis 12 (12) 2 (5) 10 (17) 0.144
TMJ disorder 11 (11) 5 (13) 6 (10) 0.959
Restless legs 11 (11) 3 (8) 8 (14) 0.547
Symptom duration, years, mean (SD)     
Gastrointestinal symptoms 29 (6) 29 (5) 29 (8) 0.029
Extraintestinal symptoms 9 (2) 9 (2) 9 (2) 0.501
Prescribed drugs , n (%)     
Analgesics * 79 (81) 34 (87) 45 (78) 0.344
Omeprazole 76 (78) 29 (74) 47 (81) 0.595
Antidepressants 65 (67) 25 (64) 40 (69) 0.780
Pregabalin 55 (57) 19 (49) 36 (62) 0.275
Benzodiazepines/hypnotics 55 (57) 20 (51) 35 (60) 0.500
Antispasmodics/Antidiarrhoeals 37 (38) 17 (38) 33 (57) 0.281
Laxatives 13 (13) 10 (26) 27 (47) 0.062
  1. Digestive complaints consisted of a combination of at least two of the following symptoms: bloating, heartburn, epigastric pain, diffuse abdominal pain, constipation and diarrhoea (separately or alternating); skin problems included: itchy/dry/burning skin, dermographism, chronic urticaria, and one case of herpetiformis dermatitis; chronic headaches encompassed: migraines, muscle tension and combination headaches; *analgesics were usually used on an irregular basis (on demand), and generally consisted of non-steroidal anti-inflammatory drugs, paracetamol, tramadol, metamizol and codeine; antidepressants: tricyclic antidepressants, selective serotonin reuptake inhibitors, other antidepressants; antispasmodics: mebeverine and/or otilonium bromide; antidiarrhoeals: loperamide, diphenoxylate/atropine. TMJ: temporomandibular joint.