Figure 2

Comparison of gene expression and histology between the normal bevacizumab and normal groups (experiment 1). (A) Synovial gene expression. (B) Subchondral bone gene expression. (C) Articular cartilage gene expression. Gene expression data are expressed as mean ± SD (n = 6 knees). The y-axis is defined as follows: 2^-ΔCT normal B target gene/2^-ΔCT normal target gene. *P <0.05 by the Mann-Whitney U-test. (D) Representative articular cartilage histology for the normal group (left side) and normal bevacizumab group (right side) stained with Safranin O. (E) Representative synovial histology for the normal group (left side) and normal bevacizumab group (right side) stained with H&E. (F) Higher magnifications of the image in (E) stained with H&E. Histology data were obtained from six knees per group. Bars = 1 mm (E); bars = 300 μm (D, F).