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Table 2 Main clinical and radiographic outcomes of poor and non-poor prognosis patients receiving initial monotherapy or initial combination therapy after 3 months and after 1 year

From: Feasibility of tailored treatment based on risk stratification in patients with early rheumatoid arthritis

  Poor prognosis patients  
  Initial mono Initial combo P-value
DAS remission    
After 3 months 5 (5) 15 (17) 0.016
After 1 year 21 (21) 31 (36) 0.034
ACR20 response    
After 3 months 35 (38) 57 (70) < 0.001
After 1 year 73 (80) 75 (93) 0.026
ACR50 response    
After 3 months 12 (13) 40 (48) <0.001
After 1 year 52 (57) 59 (71) 0.060
ACR70 response    
After 3 months 4 (4) 20 (24) <0.001
After 1 year 28 (30) 35 (44) 0.081
Decrease in HAQ score, median (IQR)   
After 3 months 0.38 (-0.63, 0.06) 0.75 (-1.13, -0.25) <0.001
After 1 year 0.75 (-1.13, -0.38) 0.88 (-1.38, -0.38) 0.110
SHS progression    
After 1 year, median (IQR) 1.5 (0, 5.0) 0 (0, 2.0) 0.001
RRP 24 (26) 8 (10) 0.006
  Non-poor prognosis patients  
  Initial mono Initial combo P -value
DAS remission    
After 3 months 7 (7) 23 (18) 0.017
After 1 year 35 (36) 43 (36) 1.000
ACR20 response    
After 3 months 38 (44) 79 (71) <0.001
After 1 year 63 (72) 96 (85) 0.024
ACR50 response    
After 3 months 12 (13) 56 (49) <0.001
After 1 year 44 (52) 77 (68) 0.027
ACR70 response    
After 3 months 3 (3) 20 (17) 0.001
After 1 year 29 (33) 45 (39) 0.380
Decrease in HAQ score, median (IQR)   
After 3 months 0.38 (-0.75, 0) 0.63 (-1.13, -0.25) <0.001
After 1 year 0.63 (-1.13, -0.13) 0.88 (-1.25, -0.31) 0.040
SHS progression    
After 1 year, median (IQR) 0 (0, 1.5) 0 (0, 1.0) 0.451
RRP 10 (11) 4 (4) 0.054
  1. Numbers indicate number of patients (percentage) unless indicated otherwise. ACR response: according to the American College of Rheumatology criteria [17]; DAS remission, disease activity score <1.6 [16]; Initial combo: initial combination therapy with either prednisone or infliximab; Initial mono: initial monotherapy with methotrexate; non-poor prognosis (presence of ≤2 of 4 poor prognostic factors); HAQ, health assessment questionnaire (scale 0 to 3); poor prognosis (presence of ≥3 of 4 poor prognostic factors); SHS, Sharp van der Heijde score; RRP, rapid radiographic progression, defined as increase in Sharp van der Heijde score ≥5 points during the first year.