Feasibility of tailored treatment based on risk stratification in patients with early rheumatoid arthritis

Table 2 Main clinical and radiographic outcomes of poor and non-poor prognosis patients receiving initial monotherapy or initial combination therapy after 3 months and after 1 year

	Poor prognosis patients
	Initial mono	Initial combo	P-value
DAS remission
After 3 months	5 (5)	15 (17)	0.016
After 1 year	21 (21)	31 (36)	0.034
ACR20 response
After 3 months	35 (38)	57 (70)	< 0.001
After 1 year	73 (80)	75 (93)	0.026
ACR50 response
After 3 months	12 (13)	40 (48)	<0.001
After 1 year	52 (57)	59 (71)	0.060
ACR70 response
After 3 months	4 (4)	20 (24)	<0.001
After 1 year	28 (30)	35 (44)	0.081
Decrease in HAQ score, median (IQR)
After 3 months	0.38 (-0.63, 0.06)	0.75 (-1.13, -0.25)	<0.001
After 1 year	0.75 (-1.13, -0.38)	0.88 (-1.38, -0.38)	0.110
SHS progression
After 1 year, median (IQR)	1.5 (0, 5.0)	0 (0, 2.0)	0.001
RRP	24 (26)	8 (10)	0.006
	Non-poor prognosis patients
	Initial mono	Initial combo	P -value
DAS remission
After 3 months	7 (7)	23 (18)	0.017
After 1 year	35 (36)	43 (36)	1.000
ACR20 response
After 3 months	38 (44)	79 (71)	<0.001
After 1 year	63 (72)	96 (85)	0.024
ACR50 response
After 3 months	12 (13)	56 (49)	<0.001
After 1 year	44 (52)	77 (68)	0.027
ACR70 response
After 3 months	3 (3)	20 (17)	0.001
After 1 year	29 (33)	45 (39)	0.380
Decrease in HAQ score, median (IQR)
After 3 months	0.38 (-0.75, 0)	0.63 (-1.13, -0.25)	<0.001
After 1 year	0.63 (-1.13, -0.13)	0.88 (-1.25, -0.31)	0.040
SHS progression
After 1 year, median (IQR)	0 (0, 1.5)	0 (0, 1.0)	0.451
RRP	10 (11)	4 (4)	0.054

Numbers indicate number of patients (percentage) unless indicated otherwise. ACR response: according to the American College of Rheumatology criteria [17]; DAS remission, disease activity score <1.6 [16]; Initial combo: initial combination therapy with either prednisone or infliximab; Initial mono: initial monotherapy with methotrexate; non-poor prognosis (presence of ≤2 of 4 poor prognostic factors); HAQ, health assessment questionnaire (scale 0 to 3); poor prognosis (presence of ≥3 of 4 poor prognostic factors); SHS, Sharp van der Heijde score; RRP, rapid radiographic progression, defined as increase in Sharp van der Heijde score ≥5 points during the first year.

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