Synovial fluid | Cartilage | ||||||||
---|---|---|---|---|---|---|---|---|---|
Cytokines (per ml SF) | Healthy (n= 20) | Defect (n=31) | Osteoarthritis (n= 27) | Pvalue | Cytokines per g tissue | Healthy (n= 9) | Defect (n= 16) | Osteoarthritis (n= 27) | Pvalue |
IL-1α (pg/ml) | 16 ± 10 (100%) | 14 ± 8 (100%) | 15 ± 22 (89%) | 0.085 | IL-1α (pg/g) | 5 ± 13 (22%) | 366 ± 706 (25%) | 183 ± 391 (26%) | 0.470 |
IL-1β (pg/ml) | 1 ± 2 (25%) | 15 ± 18 (55%) | 8 ± 16 (41%) | 0.032 | IL-1β (pg/g) | 0 ± 0 (0%) | 23 ± 63 (13%) | 0 ± 1 (4%) | 0.336 |
IL-4 (pg/ml) | 0 ± 0 (0%) | 2 ± 3 (32%) | 1 ± 4 (15%) | 0.026 | IL-4 (pg/g) | 0 ± 0 (0%) | 1 ± 2 (13%) | 0 ± 1 (7%) | 0.261 |
IL-6a (pg/ml) | 64 ± 120 (40%) | 261 ± 385 (96%) | 396 ± 508 (82%) | <0.001* | IL-6 (pg/g) | 1064 ± 3193 (11%) | 1473 ± 3162 (19%) | 935 ± 2739 (19%) | 0.752 |
IL-7 (pg/ml) | 0 ± 0 (0%) | 0 ± 0 (0%) | 5 ± 28 (4%) | 0.459 |  |  |  |  |  |
IL-8 (pg/ml) | 25 ± 29 (75%) | 27 ± 33 (59%) | 52 ± 95 (85%) | 0.352 | IL-8, ng/g | 12 ± 20 (67%) | 10 ± 30 (31%) | 15 ± 44 (48%) | 0.442 |
IL-10 (pg/ml) | 1 ± 6 (5%) | 0 ± 0 (0%) | 9 ± 35 (15%) | 0.134 | IL-10 (pg/g) | 0 ± 0 (0%) | 812 ± 2113 (13%) | 578 ± 1650 (15%) | 0.400 |
IL-13 (pg/ml) | 1 ± 2 (5%) | 38 ± 41 (64%) | 18 ± 40 (33%) | <0.001* | IL-13 (pg/g) | 0 ± 0 (0%) | 799 ± 1641 (25%) | 250 ± 648 (15%) | 0.121 |
TNFα (pg/ml) | 0 ± 0 (0%) | 2 ± 8 (9%) | 4 ± 20 (11%) | 0.324 | TNFα (pg/g) | 522 ± 1084 (22%) | 3069 ± 4453 (25%) | 1733 ± 3212 (30%) | 0.467 |
IFNγ (pg/ml) | 47 ± 17 (100%) | 68 ± 38 (100%) | 51 ± 69 (93%) | 0.001* | IFNγ (pg/g) | 0 ± 0 (0%) | 226 ± 848 (13%) | 0 ± 0 (0%) | 0.101 |
OSM (pg/ml) | 2 ± 7 (5%) | 22 ± 46 (64%) | 38 ± 121 (22%) | 0.001* | OSM (pg/g) | 66 ± 108 (44%) | 170 ± 241 (38%) | 220 ± 424 (37%) | 0.786 |
 |  |  |  |  | LIF (pg/g) | 0 ± 0 (0%) | 2797 ± 6515 (13%) | 3529 ± 10164 (22%) | 0.279 |
 |  |  |  |  | Adiponectin (μg/g) | 12 ± 10 (100%) | 57 ± 62 (88%) | 19 ± 29 (100%) | 0.002 |
 |  |  |  |  | Leptin (ng/g) | 15 ± 29 (33%) | 120 ± 169 (63%) | 112 ± 136 (83%) | 0.026 |
 |  |  |  |  | MCP1 (pg/g) | 182 ± 423 (22%) | 1336 ± 1711 (50%) | 1249 ± 1250 (68%) | 0.044 |
 |  |  |  |  | RANTES (pg/g) | 0 ± 0 (0%) | 1225 ± 2163 (31%) | 510 ± 1121 (22%) | 0.056 |
 |  |  |  |  | bFGF (ng/g) | 129 ± 335 (44%) | 439 ± 691 (69%) | 615 ± 719 (74%) | 0.055 |
 |  |  |  |  | HGF (pg/g) | 3171 ± 6757 (56%) | 5824 ± 5110 (69%) | 2986 ± 3452 (74%) | 0.113 |
 |  |  |  |  | VEGF (ng/g) | 19 ± 11 (100%) | 212 ± 149 (88%) | 49 ± 28 (100%) | <0.001* |
 |  |  |  |  | IL-1RA (pg/g) | 495 ± 1017 (22%) | 1856 ± 3172 (25%) | 2504 ± 10792 (33%) | 0.573 |